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The pharmacokinetics of Female Viagra Bitcoin Pharmacy Online in the recommended dose range is linear.

Suction. After intake of Female Viagra Bitcoin Pharmacy Online is rapidly absorbed. Absolute bioavailability averages about 40% (25 to 63%). In vitro Female Viagra Bitcoin Pharmacy Online at a concentration of about 1.7 ng/ml (3.5 nm) inhibits the activity of PDE-5 50%. After a single dose of Buy Kamagra Bitcoin 100 mg average Cmax free Female Viagra Bitcoin Pharmacy Online in plasma men is about 18 ng/ml (38 nm). Cmax when taking Female Viagra Bitcoin Pharmacy Online inside fasting is achieved for an average of 60 minutes (from 30 to 120 minutes). When taken in combination with fatty foods, the rate of absorption decreases: Cmax decreases by an average of 29%, and Tmax increases by 60 minutes, but the degree of absorption does not change significantly (AUC decreases by 11%).

Distribution. The average Vss of Buy Female Viagra With Bitcoins is 105 l. the Association of Buy Sildenafil Bitcoin and its main circulating N-demethyl metabolite with plasma proteins is about 96% and does not depend on the total concentration of the drug. Less than 0.0002% of the dose of Female Viagra Bitcoin Pharmacy Online (an average of 188 ng) was found in sperm 90 minutes after taking the drug.

Metabolism. Female Viagra Bitcoin Pharmacy Online is metabolized mainly in the liver by the action of CYP3A4 isoenzyme (main pathway) and CYP2C9 isoenzyme (minor pathway). The main circulating active metabolite, formed as a result of N-demethylation of Female Viagra Bitcoin Pharmacy Online, undergoes further metabolism. The selectivity of this metabolite against PDE is comparable to that of Female Viagra Bitcoin Pharmacy Online, and its activity against PDE-5 in vitro is about 50% of the activity of Buy Sildenafil With Bitcoin Or Credit Card. The concentration of the metabolite in the blood plasma of healthy volunteers was about 40% of the concentration of Female Viagra Bitcoin Pharmacy Online. N-demethyl metabolite undergoes further metabolism; its T1/2 is about 4 no.

Breeding. The total clearance of Female Viagra Bitcoin Pharmacy Online is 41 l/h, and the final T1/2 — 3-5 h. After oral administration, as well as after I/V, Female Viagra Bitcoin Pharmacy Online is excreted as metabolites, mainly by the intestine (about 80% oral dose) and to a lesser extent by the kidneys (about 13% oral dose).

Dosage and administration

Inside, can be taken with or without water. When taking the drug, you should put a tablet, dispersed in the oral cavity, on the tongue, after which it will quickly dissolve, and it can be swallowed. The tablet should be taken immediately after opening the blister. Patients who are recommended a dose of Kamagra Bitcoin Pharmacy Online 100 mg, the second tablet of Female Viagra Bitcoin Pharmacy Online 50 mg should be taken after complete dissolution of the first tablet.

The recommended dose for most adult patients is 50 mg approximately 1 hour before sexual activity. Taking into account the effectiveness and tolerability of the dose can be increased to 100 mg or reduced to 25 mg (only tablets coated with a film, the appropriate dosage). The maximum recommended dose is 100 mg. Patients who are recommended a dose of Female Viagra Bitcoin Pharmacy Online 100 mg, it is necessary to take 2 table., dispersible in the oral cavity, dosage 50 mg consecutively one after another. The maximum recommended frequency of use — 1 time per day. It should be borne in mind that the absorption of Viagra Bitcoin Pharmacy Online significantly slows down when used in combination with fatty foods.

Special patient groups

Renal impairment. In mild to moderate renal failure dose adjustment is not required, in severe renal failure (Creatinine CL <30 ml/min) Discount Red Viagra With Bitcoin dose should be reduced to 25 mg.

Hepatic impairment. Since the excretion of Female Viagra Bitcoin Pharmacy Online is disturbed in patients with liver damage (in particular, cirrhosis), the dose of Buy Viagra Online Bitcoin Or Credit Card should be reduced to 25 mg.

Joint application with other drugs. Joint use with ritonavir is not recommended. In any case, the maximum dose of Female Viagra Bitcoin Pharmacy Online under any circumstances should not exceed 25 mg, and the frequency of application — 1 time in 48 h (see "Interaction").

When combined with inhibitors of CYP3A4 isoenzyme (erythromycin, saquinavir, ketoconazole, Itraconazole), the initial dose of Female Viagra Bitcoin Pharmacy Online should be 25 mg (see "Interaction").

To minimize the risk of postural hypotension in patients taking α-blockers, Female Viagra Bitcoin Pharmacy Online should be started only after achieving hemodynamic stabilization in these patients. Consideration should also be given to reducing the initial dose of Buy Kamagra Bitcoin (see special instructions and Interactions).

Old age. Adjustment of the dose of Pay For Female Viagra With Bitcoin is not required.

Clinical data

Cardiac studies. The use of Female Viagra Bitcoin Pharmacy Online in doses up to 100 mg did not lead to clinically significant ECG changes in healthy volunteers. The maximum decrease in systolic pressure in the supine position after taking Female Viagra Bitcoin Pharmacy Online at a dose of 100 mg was 8.3 mm Hg.art., and diastolic pressure — 5.3 mm Hg.a More pronounced, but also transient effect on blood PRESSURE was observed in patients taking nitrates (see "Contraindications" and "Interaction").

In a study of the hemodynamic effect of Pay For Kamagra With Bitcoin in a single dose of 100 mg in 14 patients with severe coronary artery disease (more than 70% of patients had stenosis of at least one coronary artery), systolic and diastolic resting pressure decreased by 7 and 6%, respectively, and pulmonary systolic pressure decreased by 9%. Female Viagra Bitcoin Pharmacy Online did not affect cardiac output and did not interfere with blood flow in stenotic coronary arteries, and also led to an increase (by about 13%) of adenosine-induced coronary flow in both stenotic and intact coronary arteries. In a double-blind placebo-controlled study of 144 patients with erectile dysfunction and stable angina, taking antianginal drugs (except nitrates), exercise was performed until the severity of symptoms of angina increased. The duration of the exercise was significantly longer (19.9 seconds; 0.9–38.9 seconds) in patients taking Female Viagra Bitcoin Pharmacy Online in a single dose of 100 mg, compared with patients receiving placebo.

In a randomized double-blind placebo-controlled study, the effect of changing the dose of Female Viagra Bitcoin Pharmacy Online (up to 100 mg) in men (n=568) with erectile dysfunction and hypertension, taking more than two antihypertensive drugs, was studied. Female Viagra Bitcoin Pharmacy Online improved erection in 71% of men compared to 18% in the placebo group. The frequency of adverse effects was comparable to that in other groups of patients, as well as in those taking more than three antihypertensive drugs.

Studies of visual impairment. In some patients, 1 h after taking Female Viagra Bitcoin Pharmacy Online at a dose of 100 mg with the Farnsworth-Mansell test 100 revealed a slight and transient violation of the ability to distinguish shades of color (blue/green). After 2 hours after taking the drug, these changes were absent. It is believed that color vision impairment is caused by inhibition of PDE-6, which is involved in the process of color transmission in the retina. Female Viagra Bitcoin Pharmacy Online had no effect on visual acuity, contrast perception, electroretinogram, IOP or pupil diameter.

Cardiovascular complications

During the post-marketing use of Female Viagra Bitcoin Pharmacy Online for the treatment of erectile dysfunction, adverse events such as severe cardiovascular complications (including myocardial infarction, unstable angina, sudden cardiac death, ventricular arrhythmia, hemorrhagic stroke, transient ischemic attack, hypertension and hypotension) were reported, which had a temporary connection with the use of Pay For Viagra With Bitcoin. Most of these patients, but not all of them, had risk factors for cardiovascular complications. Many of these adverse events were observed shortly after sexual activity, and some were observed after taking Generic Viagra For Bitcoin without subsequent sexual activity. It is not possible to establish a direct link between the reported adverse events and those or other factors.

Visual impairment

In rare cases, during post-approval use of all of the inhibitors of PDE5, including Female Viagra Bitcoin Pharmacy Online, reported NESN is a rare disease and the cause of the decrease or loss of vision. Most of these patients had risk factors, such as decreased ratios of excavation diameter to optic disc (stagnant disc), age over 50, diabetes, hypertension, CHD, hyperlipidemia, and Smoking. In an observational study evaluated whether recent use of drugs class of inhibitors PDE-5 with an acute onset NESN. The results indicate approximately a 2-fold increase in risk of developing NESN within 5T1/2 after application of the PDE-5 inhibitor. According to published literature, the annual incidence of npins IS 2.5–11.8 cases per 100,000 men aged ≥50 years in the General population. Patients should be advised to stop Buy Viagra Online Bitcoin Or Credit Card therapy in case of sudden loss of vision and consult a doctor immediately. Persons who have already had a case NESN have an increased risk of relapse NESN. Therefore, the doctor should discuss this risk with such patients, as well as the potential chance of adverse effects of PDE-5 inhibitors. PDE-5 inhibitors, including Buy Sildenafil With Bitcoins, in such patients should be used with caution and only in situations where the expected benefit outweighs the risk.

When using the drug Female Viagra Bitcoin Pharmacy Online in doses exceeding the recommended, adverse events were similar to those noted above, but usually more common.

*Side effects identified during post-marketing studies.

Interaction

Effect of other drugs on the pharmacokinetics of Female Viagra Bitcoin Pharmacy Online

The metabolism of Female Viagra Bitcoin Pharmacy Online occurs mainly under the action of CYP3A4 isoenzyme (main pathway), so inhibitors of this isoenzyme can reduce the clearance of Buy Viagra With Bitcoins, and inducers, respectively, increase the clearance of Female Viagra Bitcoin Pharmacy Online. A decrease in the clearance of Female Viagra Bitcoin Pharmacy Online with simultaneous use of inhibitors of CYP3A4 isoenzyme (ketoconazole, erythromycin, cimetidine).

Cimetidine (800 mg), a nonspecific inhibitor of CYP3A4 isoenzyme, when taken together with Female Viagra Bitcoin Pharmacy Online (50 mg) causes an increase in the concentration of Pay For Kamagra With Bitcoin in plasma by 56%.

A single dose of 100 mg of Female Viagra Bitcoin Pharmacy Online together with erythromycin (500 mg/day 2 times a day for 5 days), a moderate inhibitor of CYP3A4 isoenzyme, while achieving a constant concentration of erythromycin in the blood, leads to an increase in the AUC of Generic Viagra For Bitcoin by 182%.

When co-administered Female Viagra Bitcoin Pharmacy Online (once 100 mg) and saquinavir (1200 mg/day 3 times daily), an inhibitor of HIV protease and of CYP3A4, on the background to achieve a constant concentration of saquinavir in the blood, Cmax of Female Viagra Bitcoin Pharmacy Online was increased by 140% and the AUC increased by 210%.

Stronger inhibitors of CYP3A4 isoenzyme, such as ketoconazole and Itraconazole, can cause more pronounced changes in the pharmacokinetics of Generic Viagra For Bitcoin.

The simultaneous use of Sale Super Viagra Accept Bitcoin (100 mg once) and ritonavir (500 mg 2 times a day), an inhibitor of HIV protease and a strong inhibitor of cytochrome P450, on the background to achieve a constant concentration of ritonavir in the blood leads to an increase in Cmax of Female Viagra Bitcoin Pharmacy Online by 300% (4 times), a AUC by 1000% (11-fold). After 24 h, the concentration of Female Viagra Bitcoin Pharmacy Online in blood plasma is about 200 ng/ml (after a single application of one Female Viagra Bitcoin Pharmacy Online — 5 ng/ml). This is consistent with the ritonavir effect on a wide range of cytochrome P450 substrates. Female Viagra Bitcoin Pharmacy Online does not affect the pharmacokinetics of ritonavir. Given these data, the simultaneous reception of ritonavir and Buy Sildenafil With Bitcoins is not recommended. In any case, the maximum dose of Female Viagra Bitcoin Pharmacy Online under any circumstances should not exceed 25 mg for 48 hours. If Female Viagra Bitcoin Pharmacy Online is taken in the recommended doses, patients receiving strong inhibitors of CYP3A4 isoenzyme at the same time, then Cmax free Female Viagra Bitcoin Pharmacy Online does not exceed 200 nm, and the drug is well tolerated.

Single administration of antacid (magnesium hydroxide/aluminum hydroxide) does not affect the bioavailability of Generic Viagra For Bitcoin.

Studies involving healthy volunteers with simultaneous use of endothelin receptor antagonist, bosentan (CYP3A4 isoenzyme inducer (moderate), CYP2C9, and possibly CYP2C19) in Css (125 mg 2 times a day) and Female Viagra Bitcoin Pharmacy Online in Css (80 mg 3 times a day) showed a decrease in AUC and Cmax Female Viagra Bitcoin Pharmacy Online by 62.6 and 52.4%, respectively. Cheap Viagra Professional Accept Bitcoin increased the AUC and Cmax of bosentan by 49.8 and 42%, respectively.

It is assumed that the simultaneous use of Female Viagra Bitcoin Pharmacy Online with powerful inducers of CYP3A4 isoenzyme, such as rifampicin, can lead to a greater decrease in the concentration of Female Viagra Bitcoin Pharmacy Online in blood plasma.

CYP2D6 isoenzyme inhibitors (SSRIs, tricyclic antidepressants), thiazide and thiazide-like diuretics, ACE inhibitors and calcium antagonists have no effect on the pharmacokinetics of Female Viagra Bitcoin Pharmacy Online.

Azithromycin (500 mg/day for 3 days) has no effect on AUC, Cmax, Tmax, excretion rate constant and T1/2 Generic Sildenafil For Bitcoin or its main circulating metabolite.

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